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Treatments / Procedures / EndoStim

EndoStim is a minimally invasive procedure that treats GORD (Gastro Oesophageal Reflux Disease) through neurostimulation therapy. EndoStim is designed to restore normal function to the lower oesophageal sphincter, it does this with the use of neuromodulation therapy which can be personalised for the individual patient. This treatment makes no changes to the patient’s natural anatomy and, in turn, this means the patient tends to avoid typical Gastro-Intestinal side effects.

How does it work?

The EndoStim procedure involves the neurostimulation system in the device emitting mild electrical signals to the lower oesophageal sphincter. This gently restores regular function to the lower oesophageal sphincter and, in most cases, isn’t felt by patients. This stimulation then allows the lower oesophageal sphincter valve to function as it was meant to. It stops reflux but allows food and drink to pass through to the stomach normally.

What is the device?

The EndoStim System itself is a neurostimulator or IPG (Implantable Pulse Generator), an implantable bipolar lead and, finally, a wireless external programmer which is used in in the RefluxUK clinic. The IPG (Implantable Pulse Generator) is what administers the neurostimulation therapy to the lower oesophageal sphincter through the lead. The second generation device’s battery lasts around 7 years and a first generation device’s battery lasts around 10 years.

How is it performed?

As with LINX and Fundoplication surgeries, the surgery is performed using the laparoscopic (keyhole) method. Once the EndoStim device is in place, it is programmed wirelessly by a physician after surgery. This can be adjusted in aftercare sessions with a doctor or nurse.

The minimally invasive procedure lasts around an hour. During this time 2 small electrodes are positioned on the lower esophagus and the EndoStim neurostimulator is placed under the skin in an abdominal pocket. Most patients recover quickly and will be able to get back to normal life after 5 to 7 days.


Studies show that Endostim is effective with 90% of patients medication free after two years.

Endostim FAQs

  • What is EndoStim?

    EndoStim is a revolutionary minimally invasive, neurostimulation therapy for gastro-oesophageal reflux disease (GORD).

  • Who is EndoStim for?

    Patient who have objective evidence of reflux disease, tried medication for at least one year and who are dissatisfied, those with no hiatus hernia.

  • Will I be cured?

    Clinical results for EndoStim are positive with many people reporting good symptom control over 4 years, however as with any treatment there is a chance of continuing to suffer from symptoms or of unwanted side effects from the treatment. Your doctor will be able to advise you in more detail on this.

  • When will I start receiving therapy?

    Your doctor will tell you when your device will be activated, typically during the operation or in the hospital before discharge.

  • How is my therapy set? Can it be changed?

    Your therapy will be activated with default settings that are expected to resolve most or all your symptoms. However, if after one month you still have remaining frequent or bothersome symptoms, your doctor may adjust your therapy during a clinic visit.

  • Can I pass through airport screening systems?

    Yes! At airport security, inform security staff that you have an implanted medical device and show them your identification card. No damage to the implanted system should occur.

  • Can I have an MRI test?

    With the EndoStim II system, you may safely undergo full body MRI scans under specific conditions. With the EndoStim I system, you may undergo MRI scans of your head or extremities (limbs) only under specific conditions specified in EndoStim’s user manuals. Consult your doctor prior to undergoing any MRI scan to ensure all safety precautions are observed.

  • What are the typical side effects?

    The most common side effects are irritation, pain, and/or swelling at the stimulator and/or the lead implant site. Most discomfort resolves in less than one month. For a full list of possible side effects, please consult your doctor.

  • Will I feel the stimulation?

    You should not feel the stimulation. If you feel the stimulation, please inform your doctor.

  • How long does the battery last?

    There are two versions of the EndoStim device. The EndoStim I system has a battery which lasts approximately 10 years. The EndoStim II system, a smaller device, has a battery which lasts approximately 7 years. At the end of the device’s battery life, the device can be replaced by your doctor in a simple procedure. Your doctor will explain or demonstrate this to you.

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