In this section we have selected scientific papers that have been published in peer reviewed journals which we have found particularly interesting or that are acknowledged as important. The selection is in no way comprehensive and is simply intended as a resource for those wishing to read some of the academic evidence supporting the current treatment of Gastro Oesophageal Reflux. Where possible the links are to the full article but for copyright reasons, if this is not possible, they are to abstracts.
Periodically we will be adding more scientific papers which we believe to be of particular interest with comment from one of our expert reflux surgeons. The first two papers highlighted below are such papers.
We will be adding more papers as well as recommendations from professional associations and societies incrementally and would welcome any suggestions for further additions from interested readers.
Adverse Effects Associated With Proton Pump Inhibitors
“This is an interesting editorial published in the same edition of The Journal of the American Medical Association as the latest study showing a potential risk from PPIs, this time in terms of chronic renal failure.
The authors have reviewed all the available published evidence on the risks of PPIs. In their view this “suggests that PPI use is associated with an increased risk of both acute and chronic kidney disease, hypomagnesemia, c difficle infection and osteoporotic fractures.” They make the point the point that much of the available data is derived from observational studies rather than prospective randomised trials but nonetheless suggest that adverse effects have been documented by "multiple high-quality observational studies and are likely causal."
The evidence does seem to be mounting that PPIs are not as risk free as has been historically assumed. All patients considering taking these drugs long term should be aware of these risks and discuss the alternatives with their general practitioner or physian.
Long-Term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux.
“The results from this study are consistent with the previously published research. The LINX appears to offer safe and durable control of reflux symptoms. At five years following surgery the overwhelming majority of patients were no longer taking PPIs and the side effects often seen after routine laparoscopic fundoplication appears not to be a problem. On the basis of the available evidence clinicians treating patients with GORD should consider offering LINX to all patients considering a long term solution to their reflux and I urge them to read this paper”
Oesophageal Cancer and Anti-reflux surgery
- Antireflux Surgery and Risk of Esophageal Adenocarcinoma: A Systematic Review and Meta-analysis. Annals of surgery. Maret-Ouda et al. 2015
- Risk factors for esophageal adenocarcinoma after antireflux surgery. Löfdahl et al. Annals of Surgery. 2013
- Antireflux Surgery and the Risk of Esophageal Adenocarcinoma. An Antithetical View of the Data From Sweden. Annals of Surgery. DeMeester. 2013
- Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma. New England Journal of Medicine. Lagergren et al. 1999
- Systematic review: the epidemiology of gastro-oesophageal reflux disease in primary care, using the UK General Practice Research Database Alimentary Pharmacology & Therapeutics. El-Seragi et al. 2008
- Risk factors affecting the Barrett's metaplasia-dysplasia-neoplasia sequence. World J Gastrointest Endosc. Craig S Brown and Michael B Ujiki. 2015
- Laparoscopic Antireflux Surgery vs Esomeprazole Treatment for Chronic GERDThe LOTUS Randomized Clinical Trial. Journal American Medical Association. Galmiche et al. 2011
- Seven-year follow-up of a randomized clinical trial comparing proton-pump inhibition with surgical therapy for reflux oesophagitis. British Journal of Surgery. Lundell et al. 2007
- Prospective trial of laparoscopic Nissen fundoplication versus proton pump inhibitor therapy for gastroesophageal reflux disease: Seven-year follow-up. J Gastrointest Surg. Mehta et al. 2006
- Long-Term Results of a Randomized Prospective Study Comparing Medical and Surgical Treatment of Barrett’s Esophagus. Annals of Surgery. Parrilla et al. 2003
- A randomized controlled trial of laparoscopic nissen fundoplication versus proton pump inhibitors for treatment of patients with chronic gastroesophageal reflux disease: One-year follow-up. Surgical Innovovations. Anvari et al. 2006
- Long-term Outcome of Medical and Surgical Therapies for Gastroesophageal Reflux DiseaseFollow-up of a Randomized Controlled Trial. Journal of American Medical Association. Spechler et al. 2001
- Long-Term Results of a Randomized Prospective Study Comparing Medical and Surgical Treatment of Barrett’s Esophagus. Annals of Surgery. Parilla et al. 2003
PPI use after fundoplication
PPIs related complications
- Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease. Journal American Medical Association. Lazarus et al. 2016
- FDASafety Announcement 2012 PPIs & C Diff
- Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study. British Medical Journal. Khalili et al. 2012
- Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. PLoS One. Shah et al. 2015
- Proton Pump Inhibitors: The Culprit for Barrett’s Esophagus? Frontiers in Oncology. Alsalah et al. 2014
- Esophageal Sphincter Device for Gastroesophageal Reflux Disease New England Journal of Medicine. Ganz et al. 2013
- Laparoscopic Magnetic Sphincter Augmentation vs Laparoscopic Nissen Fundoplication: A Matched-Pair Analysis of 100 Patients. J Am Coll Surg. Reynolds et al. 2015
- Long-Term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux. Clin Gastroenterol Hepatol. Ganz et al. 2015
- One Hundred Consecutive Patients Treated with Magnetic Sphincter Augmentation for Gastroesophageal Reflux Disease: 6 Years of Clinical Experience from a Single Center. Journal American College of Surgeons. Bonavina et al. 2013