Scientific papers

In this section we have selected scientific papers that have been published in peer reviewed journals which we have found particularly interesting or that are acknowledged as important. The selection is in no way comprehensive and is simply intended as a resource for those wishing to read some of the academic evidence supporting the current treatment of Gastro Oesophageal Reflux. Where possible the links are to the full article but for copyright reasons, if this is not possible, they are to abstracts.

Periodically we will be adding more scientific papers which we believe to be of particular interest with comment from one of our expert reflux surgeons. The first two papers highlighted below are such papers. 

We will be adding more papers as well as recommendations from professional associations and societies  incrementally and would welcome any suggestions for further additions from interested readers.

Adverse Effects Associated With Proton Pump Inhibitors 

Read paper at jamanetwork website

“This is an interesting editorial published in the same edition of The Journal of the American Medical Association as the latest study showing a potential risk from PPIs, this time in terms of chronic renal failure. 

The authors have reviewed all the available published evidence on the risks of PPIs. In their view this “suggests that PPI use is associated with an increased risk of both acute and chronic kidney disease, hypomagnesemia, c difficle infection and osteoporotic fractures.” They make the point the point that much of the available data is derived from observational studies rather than prospective randomised trials but nonetheless suggest that adverse effects have been documented by "multiple high-quality observational studies and are likely causal." 

The evidence does seem to be mounting that PPIs are not as risk free as has been historically assumed. All patients considering  taking these drugs long term should be aware of these risks and discuss the alternatives with their general practitioner or physian.

Long-Term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux.

Read paper at ncbi website

“The results from this study are consistent with the previously published research. The LINX appears to offer safe and durable control of reflux symptoms. At five years following surgery the overwhelming majority of patients were no longer taking PPIs and the side effects often seen after routine laparoscopic fundoplication appears not to be a problem. On the basis of the available evidence clinicians treating patients with GORD should consider offering LINX to all patients considering a long term solution to their reflux and I urge them to read this paper”

Oesophageal Cancer and Anti-reflux surgery

Oesophageal Cancer

Fundoplication Papers

PPI use after fundoplication

PPIs related complications